Formin Homology Domain

by destroyer2012, published

Formin Homology Domain by destroyer2012 Mar 26, 2012

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Formins are proteins that regulate actin filament formation by staying attached to the growing end of filaments and stepping along as new monomers are added to the actin polymer. They protect the growing filament from capping protein, a protein that blocks the formation of unwanted filaments. This is the FH2 (Formin Homology 2) domain of bni1p, a yeast formin (1y64 on pdb).

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Bre Pettis

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Print out both halves, glue them together. The full FH2 domain is a dimer with each monomer holding on to the other monomer by the use of a "lasso" domain. So to be fully true to biology you should print the file out twice and glue a string to represent the flexible linker. See photos for encouragement.

Bni1p_sideways has a single monomer with its own lasso on a stick (the linker)

Bni1p_withlasso_try2 has a single monomer with the other monomer's lasso wrapped around its post domain without the linker, allowing you to glue rope or something to represent it.