Hi Greenbull. I haven't ever had a problem grabbing the bottles myself, but my fingers are pretty thin. I would say the orientation does not allow you to "quick draw" the paints but then again I don't know what kind of painting technique would require that! :)
I think the best way to know would be to try a set yourself and see if the size is to your liking. My primary goal was to save space and put them on the wall when not in use.