When I bought my printer it came with the first generation motherboard. That motherboard had a stepper driver fail, so I replaced the motherboard with Rumba motherboard.
It's definitely possible to do this, the problem I had was that I had to make a brand-new motherboard mounting solution. I decided to mount the motherboard on the outside of the printer, which then meant I had additional problems with having to lengthen all the wires too...
I got sick of the unreliable issues and long wires going everywhere, so I eventually asked JGAurora and purchased the new motherboard.
Is it possible? Yes. Would recommend it? Maybe not, depending on your skill level.