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Yes it will prevent operation if the thermistor bare wires touch the heater wires etc etc. Also if they short out heater + to heater - (THIS IS WHAT IS GOING ON WITH BLACK AND RED WIRE IN YOUR PICTURE), basically if any cross it tards your board until they are all uncrossed. I had a similar issue and had to open the bottom and redo the wires. As long as you dont leave it sitting there shorting itself out for days I think your board will survive. Mine did. Just keep it off until you investigate everything because this is a potential fire hazard when this happens.