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rather than calbrating using extrusion multipliers you would be far better off doing a proper estep calibration and hard setting your esteps to the correct distance.

Bare in mind even the amount of torque on the extruder grub screw, the wear in the teeth, variance in the machined parts, the resistance in the bowden etc... All of these things make small impact on the estep calibration but add it all together and you can have quite the dramatic shift.