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Thanks for posting this tip!

Alternatively, replace ~ with /Users/your-account-name/ to put it in your login directory or /Users/your-account-name/Desktop to put it on your Desktop.

At issue will be what does the HOME environment variable translate to in the process which Inkscape forks to run Python and the extension script. This can conceivably change with the X11 implementation (there are several for OS X), the Inkscape version (many), and maybe even your account's .profile file or other (hidden) login scripts. Hard to say. I'm a Mac user and I don't see this behavior on OS X 10.7.5 (Lion). But clearly YMWV (your mileage will vary).