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Do you mean changing from the coordinate system based motion to model view based motion OR do you mean that you need to invert the stepper motors for more than one axis? For the former, you can only do that if you have a Gen 4 LCD display. It's part of the jog menu where you change the MODE by pressing the "SET" button (center button on the rightmost column of buttons). If you mean the latter -- inverting an axis -- then you do that via ReplicatorG's Machine > Onboard Preferences screen.