I printed them in clear filament so they can lay over a DNA sequence and you can find where they match.
Break all sharp edges. If you can't see the lettering, use a permanent marker to highlight the edge of the letters.
Print 2 of each enzyme so you can model the cutting pattern and cleaved fragments.
After printing break any sharp edges. I found a emery board works great for rough edges. If you print clear, use a permanent marker to highlight the edge of the lettering.
Design and printing
These were designed in TinkerCAD based on the previous DNA / RNA file.
They were designed to fit as one piece so you can see how they work, and save time building them with the other set.
If you want to expand and make your own, DL my expansion set here http://www.thingiverse.com/thing:1321230
Project: Gene Splicing and Restriction Enzymes
Students will understand what genetic modification is.
Students will model how restriction enzymes work.
Students will model gene splicing.
Students will demonstrate how to alter DNA.
Students will discuss the ethics and implications of genetic modification.
Students will discuss genetically modified organisms (GMO's) and agriculture.
Students will show their knowledge of DNA and RNA.
Students will model how mecumbant DNA works.
Students will show sticky ends, fragments, and cleavage of DNA.
This is for AP Biology, College Bio, Medical students, and home school students.
This can also be used by genetic councilors, doctors, and medical students.
Students should learn about DNA and RNA.
Students should understand vectors and the concepts of gene splicing.
Students should know about mutations.
Students should know what paladrones are, and how they appear in DNA.
Students should know what an enzyme does.
Students should know the base pairs, what direction (5
- 3) DNA is read.
To use these restriction enzymes, you should print up 2 of them along with the DNA / RNA set.
A activity package will soon be available, and sold on my Teacher Pay Teacher page. Printed sets of restriction enzymes will be for sale on my etsy page.
a. Build a model of DNA matching the restriction enzyme.
b. Model how the restriction enzyme cuts the DNA along specific base pairs.
c. Show where the sticky ends are.
d. Use the enzymes to insert a new DNA sequence.
e. Discuss gene splicing. Show organisms that have undergone this procedure.
f. Discuss the ethics on gene splicing.
To demonstrate knowledge of this, have the students work in small groups to demonstrate the process or teach it to others.
You can have the students make a stop-motion video of the process of gene splicing.
You can also have them show what they have learned by modeling DNA replication, RNA transcription, protein synthesis, and gene splicing to produce new proteins.
You can tie it to pop science by having them watch sections of the film Jurassic Park / Jurassic World that discuss what they did to create the dinosaurs. With that have the students model what the scientist in the film did.